Ascorbic Acid 500 MG/ML Injectable Solution
Generic Name: ASCORBIC ACID
Brand Name: Ascorbic Acid
- Substance Name(s):
- ASCORBIC ACID
WARNINGS
Diabetics, patients prone to renal calculi, those undergoing stool occult blood tests and those on sodium restricted diets or anticoagulant therapy should not take excessive doses of ascorbic acid over an extended period of time.
DESCRIPTION
Ascorbic Acid (vitamin C) is a water-soluble vitamin.
It occurs as a white or slightly yellow crystal or powder with a light acidic taste.
It is an antiscorbutic product.
On exposure to air and light it gradually darkens.
In the dry state it is reasonably stable in air, but in solution it rapidly oxidizes.
Ascorbic Acid is freely soluble in water; sparingly soluble in alcohol; insoluble in chloroform, ether, and benzene.
The chemical name of Ascorbic Acid is L-ascorbic acid.
The molecular formula is C 6H 80 6 and the molecular weight is 176.13.
The structural formula is as follows: Ascorbic Acid injection is a clear, colorless to slightly yellow sterile solution of Ascorbic Acid in Water for Injection, for intravenous, intramuscular or subcutaneous use.
Each mL contains: Ascorbic Acid 500 mg, Edetate Disodium 0.25 mg, Water for Injection q.s.
pH (range 5.5-7.0) adjusted with Sodium Bicarbonate and Sodium Hydroxide.
Contains no preservatives.
structural formula
HOW SUPPLIED
Ascorbic Acid for Injection, USP (500mg/mL) NDC 69877-017-01 50mL Sterile Dispensing Vial, individually boxed, Rx only NDC 69877-017-10 50 mL Sterile Dinspensing Vial, packaged in boxes of 10 vials, Rx only PROTECT FROM LIGHT.
STORE IN CARTON UNTIL TIMEOF USE: Store between 2° to 8°C (36° to 46°F).
Rev.
07/15
INDICATIONS AND USAGE
Ascorbic acid is recommended for the prevention and treatment of scurvy.
Its parenteral administration is desirable for patients with an acute deficiency or for those whose absorption of orally ingested ascorbic acid is uncertain.
Symptoms of mild deficiency may include faulty bone and tooth development, gingivitis, bleeding gums, and loosened teeth.
Febrile states, chronic illness, and infection (pneumonia, whooping cough, tuberculosis, diphtheria, sinusitis, rheumatic fever, etc.) increases the need for ascorbic acid.
Hemovascular disorders, burns, delayed fracture and wound healing are indications for an increase in the daily intake.
DOSAGE AND ADMINISTRATION
Ascorbic acid is usually administered orally.
When oral administration is not feasible or when malabsorption is suspected, the drug may be administered intramuscularly, intravenously or subcutaneously.
When given parenterally, utilization of the vitamin reportedly is best after IM administration, which is the preferred parenteral route.
For intravenous injection, dilution into a large volume parenteral such as Normal Saline or Glucose is recommended to minimize the adverse reactions associated with intravenous injection.
The average protective dose of ascorbic acid for adults is 70 to 150 mg daily.
In the presence of scurvy, doses of 300 mg to 1 gram daily are recommended.
However, as much as 6 grams have been administered parenterally to normal adults without evidence of toxicity.
To enhance wound-healing, doses of 300 to 500 mg daily for a week to ten days, both preoperatively and postoperatively, are generally considered adequate, although considerably larger amounts have been recommended.
In the treatment of burns, doses are governed by the extent of tissue injury.
For severe burns, daily doses of 1 to 2 grams are recommended.
In other conditions in which the need for ascorbic acid is increased, three to five times the daily optimum allowances appear to be adequate.